Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5alpha but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Laura M J Ylinen, Amanda J Price, Jane Rasaiyaah, Stéphane Hué, Nicola J Rose, Flavia Marzetta, Leo C James, Greg J Towers
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-08-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001062&type=printable