Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry

Canonical inflammasome activation is a tightly regulated process that has been implicated in a broad spectrum of inflammatory disorders. Inflammasome formation requires assembly of a cytosolic sensor protein with the adapter, ASC (apoptosis-associated speck-like protein containing a caspase activati...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Silvia Lucena Lage, Venina Marcela Dominical, Chun-Shu Wong, Irini Sereti
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-06-01
Subjects:	inflammasome ASC speck multispectral imaging flow cytometry (MIFC) monocytes caspase-1
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01284/full