CREB3 gain of function variants protect against ALS

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly evolving neurodegenerative disease arising from the loss of glutamatergic corticospinal neurons (CSN) and cholinergic motoneurons (MN). Here, we performed comparative cross-species transcriptomics of CSN using published snRNA-seq da...

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Bibliographic Details
Published in:Nature Communications
Main Authors: Salim Megat, Christine Marques, Marina Hernán-Godoy, Chantal Sellier, Geoffrey Stuart-Lopez, Sylvie Dirrig-Grosch, Charlotte Gorin, Aurore Brunet, Mathieu Fischer, Céline Keime, Pascal Kessler, Marco Antonio Mendoza-Parra, Ramona A. J. Zwamborn, Jan H. Veldink, Sonja W. Scholz, Luigi Ferrucci, Albert Ludolph, Bryan Traynor, Adriano Chio, Luc Dupuis, Caroline Rouaux
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Online Access:https://doi.org/10.1038/s41467-025-58098-6

Internet

https://doi.org/10.1038/s41467-025-58098-6

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