Genetic deletion of 12/15 lipoxygenase delays vascular remodeling and limits cardiorenal dysfunction after pressure overload

The lipid metabolizing enzyme 12/15 lipoxygenase (12/15LOX) induces proinflammatory responses that may increase cardiovascular and renal complications after cardiac insult. To define the role of 12/15LOX, 8–12-week-old male C57BL/6J wild-type (WT; n = 49) and 12/15LOX−/− mice (n = 50) were subject t...

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Bibliographic Details

Published in:	Journal of Molecular and Cellular Cardiology Plus
Main Authors:	Dae Hyun Lee, Vasundhara Kain, Da-Zhi Wang, Donald G. Rokosh, Sumanth D. Prabhu, Ganesh V. Halade
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Subjects:	Heart failure Inflammation-resolution signaling Lipid mediators Lipoxygenase Pressure overload Transverse aortic constriction
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772976123000168