Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes

Abstract Background De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased community functioning. Several DNMs have been identified by examining...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy, Mária Judit Molnár, László Homolya, Zsófia Nemoda, Ágota Apáti, János M. Réthelyi
Format:	Article
Language:	English
Published:	BMC 2020-11-01
Subjects:	Schizophrenia Autism DNM KHSRP LRRC7 iPSC
Online Access:	https://doi.org/10.1186/s13287-020-01980-5