A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress

Abstract Pathological cardiac remodeling is a maladaptive response that leads to changes in the size, structure, and function of the heart. These changes occur due to an acute or chronic stress on the heart and involve a complex interplay of hemodynamic, neurohormonal and molecular factors. As a cri...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Maja Bencun, Laura Spreyer, Etienne Boileau, Jessica Eschenbach, Norbert Frey, Christoph Dieterich, Mirko Völkers
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Subjects:	Hypertrophic growth Upstream open reading frame Folliculin Translation TFEB Lysosome
Online Access:	https://doi.org/10.1038/s41598-025-87107-3