Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses

Diphyllin is a natural arylnaphtalide lignan extracted from tropical plants of particular importance in traditional Chinese medicine. This compound has been described as a potent inhibitor of vacuolar (H<sup>+</sup>)ATPases and hence of the endosomal acidification process that is require...

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Bibliographic Details
Published in:Viruses
Main Authors: Michal Štefánik, Dattatry Shivajirao Bhosale, Jan Haviernik, Petra Straková, Martina Fojtíková, Lucie Dufková, Ivana Huvarová, Jiří Salát, Jan Bartáček, Jan Svoboda, Miloš Sedlák, Daniel Růžek, Andrew D. Miller, Luděk Eyer
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Subjects:
enveloped virus
diphyllin
cleistanthin B
vacuolar ATPase inhibitor
antiviral activity
cytotoxicity
Online Access:https://www.mdpi.com/1999-4915/14/2/354

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https://www.mdpi.com/1999-4915/14/2/354

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