Macrophage DGKζ-mediated phosphatidic acid remodeling aggravates acute liver failure

Acute liver failure (ALF) is a life-threatening condition associated with macrophage-mediated inflammatory responses. Effective therapies and drugs are still lacking to date. Here, we reveal that a derivative of xanthohumol, CAM12203, alleviates lipopolysaccharide (LPS) + d-galactosamine (D-GalN)-in...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Yumeng Miao, Tzuchun Lin, Bianlin Wang, Junyu Xu, Chongxian Li, Zuopeng Li, Xinwen Zhang, Chendong Zhou, Tuerganaili Aji, Minjia Tan, Haji Akber Aisa, Jingya Li
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Subjects:	Xanthohumol derivative Macrophages Acute liver failure Diacylglycerol kinase ζ Phosphatidic acid Signal transducer and activator of transcription 3
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383525004393