Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in multiple myeloma (MM). Hypersialylation can lead to increased immune evasion, drug resistance, tumor invasiveness, and...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Alessandro Natoni, Mariah L. Farrell, Sophie Harris, Carolyne Falank, Lucy Kirkham-McCarthy, Matthew S. Macauley, Michaela R. Reagan, Michael O’Dwyer
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2020-02-01
Online Access:	https://haematologica.org/article/view/9530