A phase 1b randomised clinical trial evaluating BBI-001, a non-absorbed oral therapeutic for the treatment of iron overload

Abstract Non-transfusion-dependent iron overload is the result of excessive dietary iron absorption, most commonly caused in populations of European descent by the genetic disorder HFE-related hemochromatosis (HH). In this disorder, hyperabsorption of 3–5 mg of iron per day cannot be counterbalanced...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Curtis Scribner, Jamie Cope, Philip Ryan, John K. Olynyk, John Ryan, J. Daniel Griffin, Cory Berkland
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41598-025-01421-4