A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice

We recently developed a molecule (GT-73) that blocked leukocyte transendothelial migration from blood to the peripheral tissues, supposedly by affecting the platelet endothelial cell adhesion molecule (PECAM-1) function. GT-73 was tested in an LPS-induced acute respiratory distress syndrome (ARDS) m...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Eliav Blum, Raanan Margalit, Laura Levy, Tamar Getter, Ron Lahav, Sofia Zilber, Paul Bradfield, Beat A. Imhof, Evgenia Alpert, Arie Gruzman
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Subjects:	ARDS leukocyte transmigration cytokine storm PECAM-1 covalent inhibitor
Online Access:	https://www.mdpi.com/1420-3049/26/15/4583