The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer

Abstract GPRC5D is an atypical Class C orphan G protein-coupled receptor. Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers. Despite its therapeutic potent...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Pengfei Yan, Xi Lin, Lijie Wu, Lu Xu, Fei Li, Junlin Liu, Fei Xu
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Online Access:	https://doi.org/10.1038/s41467-024-49625-y