MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes

Acute respiratory distress syndrome (ARDS) following cardiopulmonary bypass (CPB) is driven by oxidative stress during lung ischemia-reperfusion injury (LIRI). Mitochondrial-derived peptide MOTS-c has emerged as a regulator of mitochondrial-nuclear communication, yet its role in CPB-induced ARDS rem...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Xiangyu Li, Faliang Zhan, Guangfeng Qiu, Peng Lu, Zihao Shen, Yuanpu Qi, Minchao Wu, Mingyu Chu, Jia Feng, Ziang Wen, Xin Yao, Ao Wang, Wanjun Jin, Xiao Zhang, Junjie Liao, Jialin Zhang, Meijuan Song, Wei Wang, Xiaowei Wang
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Subjects:	Acute respiratory distress syndrome Cardiopulmonary bypass Ischemia reperfusion injury Oxidative stress MOTS-c MYH9
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725001946