Development and evolution of human glutaminyl cyclase inhibitors (QCIs): an alternative promising approach for disease-modifying treatment of Alzheimer's disease

Human glutaminyl cyclase (hQC) is drawing considerable attention and emerging as a potential druggable target for Alzheimer's disease (AD) due to its close involvement in the pathology of AD via the post-translational pyroglutamate modification of amyloid-β. A recent phase 2a study has shown pr...

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發表在:	Frontiers in Aging Neuroscience
Main Authors:	Daoyuan Chen, Qingxiu Chen, Xiaofei Qin, Peipei Tong, Liping Peng, Tao Zhang, Chunli Xia
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2023-08-01
主題:	Alzheimer's disease human glutaminyl cyclase amyloid-β pyroglutamate modification QC inhibitor PQ912
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1209863/full