Fabry Disease and Inflammation: Potential Role of p65 iso5, an Isoform of the NF-κB Complex

Fabry disease (FD) is an X-linked lysosomal storage disease, caused by mutations in the <i>GLA</i> gene on the X chromosome, resulting in a deficiency of the lysosomal enzyme α-GAL. This leads to the progressive accumulation of Gb3 in cells, causing multi-systemic effects. FD has been cl...

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Bibliographic Details

Published in:	Cells
Main Authors:	Giuseppa Biddeci, Gaetano Spinelli, Paolo Colomba, Giovanni Duro, Monia Anania, Daniele Francofonte, Francesco Di Blasi
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	Fabry disease inflammation NF-κB p65 p65 iso5
Online Access:	https://www.mdpi.com/2073-4409/14/3/230