Knockout of P2Y12 receptor facilitates neuronal envelopment by reactive microglia and accelerates prion disease

Abstract Background Microglia continuously monitor neuronal health through somatic purinergic junctions, where microglial processes establish dynamic contacts with neuronal cell bodies. The P2Y12 receptor is a key component of these junctions, essential for intercellular communication between ramifi...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Natallia Makarava, Tarek Safadi, Olga Bocharova, Olga Mychko, Narayan P. Pandit, Kara Molesworth, Ukpong B. Eyo, Ilia V. Baskakov
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Prions Prion diseases Neurodegenerative diseases P2Y12 receptor Reactive microglia Microglia-neuron interactions; microglia mobility
Online Access:	https://doi.org/10.1186/s12974-025-03542-z