Peptidylarginine deiminase 4 deficiency in bone marrow cells prevents plaque progression without decreasing atherogenic inflammation in apolipoprotein E-knockout mice

IntroductionDespite multiple studies in the past, the role of peptidylarginine deiminase 4 (PAD4) in atherosclerosis is currently insufficiently understood. In this regard, PAD4 deletion or inhibition of enzymatic activity was previously reported to ameliorate disease progression and inflammation. B...

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Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Adnana Paunel-Görgülü, Andreas Conforti, Natalia Mierau, Mario Zierden, Xiaolin Xiong, Thorsten Wahlers
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	peptidylarginine deiminase 4 atherosclerosis macrophage polarization inflammation bone marrow reconstitution
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.1046273/full