Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

Cell surface HLA-I molecules (Face-1) consist of a polypeptide heavy chain (HC) with two groove domains (G domain) and one constant domain (C-domain) as well as a light chain, B2-microglobulin (B2m). However, HCs can also independently emerge unfolded on the cell surface without peptides as B2m-free...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Mepur H. Ravindranath, Narendranath M. Ravindranath, Senthamil R. Selvan, Fatiha El Hilali, Carly J. Amato-Menker, Edward J. Filippone
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	human leukocyte antigens beta2-microglobulin heavy chains monomers homodimers heterodimers
Online Access:	https://www.mdpi.com/2218-273X/13/8/1178