Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease

Alcohol-associated liver disease represents a significant global health challenge, with gut microbial dysbiosis and bacterial translocation playing a critical role in its pathogenesis. Patients with alcohol-associated hepatitis had increased fecal abundance of mammalian viruses, including retrovirus...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Noemí Cabré, Marcos F. Fondevila, Wenchao Wei, Tomoo Yamazaki, Fernanda Raya Tonetti, Alvaro Eguileor, Ricard Garcia-Carbonell, Abraham S. Meijnikman, Yukiko Miyamoto, Susan Mayo, Yanhan Wang, Xinlian Zhang, Thorsten Trimbuch, Seija Lehnardt, Lars Eckmann, Derrick E. Fouts, Cristina Llorente, Hidekazu Tsukamoto, Peter Stärkel, Bernd Schnabl
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2025-07-01
Subjects:	Gastroenterology Hepatology
Online Access:	https://doi.org/10.1172/JCI188541