A robust high-throughput screening system to assess bacterial tyrosine ammonia lyase activity in the context of tyrosine inherited metabolic disorders

Abstract Inborn errors of tyrosine metabolism result in patient’s inability to degrade tyrosine. Current treatment consists of a phenylalanine and tyrosine restricted diet and nitisinone, causing a block in the tyrosine degradation pathway. However, tyrosine levels will increase, leading to acquired...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ine Nulmans, Camille Annie Laga, Nina Stefanie Salvi, Liesbeth Desmet, Sien Lequeue, Jessie Neuckermans, Ulrich Schwaneberg, Joery De Kock
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Subjects:	Hypertyrosinemia Inborn errors of tyrosine metabolism High-throughput screening system Tyrosine ammonia lyases
Online Access:	https://doi.org/10.1038/s41598-024-72360-9