16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis

Summary: The complex 16p11.2 deletion syndrome (16pdel) is accompanied by neurological disorders, including epilepsy, autism spectrum disorder, and intellectual disability. We demonstrated that 16pdel iPSC differentiated neurons from affected people show augmented local field potential activity and...

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Bibliographic Details

Published in:	iScience
Main Authors:	Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour, Jasmine M. McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H. Futerman, Hazel Sive
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	Cellular neuroscience Developmental neuroscience Molecular neuroscience Neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221015212