The effect of icotinib or apatinib on the pharmacokinetic profile of oxycodone in rats and the underlying mechanism

This study aimed to investigate the interactions between icotinib/apatinib and oxycodone in rats and to unveil the underlying mechanism. An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to determine oxycodone and its demethylated met...

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書誌詳細

出版年:	PeerJ
主要な著者:	Qi Zhou, Feng Ye, Zhize Ye, Nanyong Gao, Qihui Kong, Xiaoqin Hu, Jianchang Qian, Bin Wu
フォーマット:	論文
言語:	英語
出版事項:	PeerJ Inc. 2023-12-01
主題:	Icotinib Apatinib Oxycodone UPLC-MS/MS Interaction
オンライン･アクセス:	https://peerj.com/articles/16601.pdf