Cohort-based pan-cancer analysis and experimental studies reveal ISG15 gene as a novel biomarker for prognosis and immunotherapy efficacy prediction

Abstract ISG15, an interferon-stimulated ubiquitin-like protein, plays a multifaceted role in tumorigenesis and immune regulation. This study comprehensively evaluates ISG15 as a prognostic biomarker and predictor of immunotherapy response through pan-cancer bioinformatics analysis and experimental...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Cancer Immunology, Immunotherapy
المؤلفون الرئيسيون:	Jingjing Wei, Yingjia Zhuang, Chengfei Jiang, Lingyan Chen, Binbin Yuan, Yue Zhao, Happi Li, Jian-Hua Mao, Bo Hang, Chunping Ye, Lei Wang, Pin Wang
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Springer 2025-04-01
الموضوعات:	Interferon-stimulated gene ISG15 Pan-cancer Tumor microenvironment Prediction of immunotherapy efficacy Immune checkpoint inhibitors Prognostic biomarkers
الوصول للمادة أونلاين:	https://doi.org/10.1007/s00262-025-04026-y