DMC-BH derivative DMC-GF inhibits the growth of glioma stem cells by targeting the TRIM33/SLC25A1/mitochondrial oxidative phosphorylation pathway

Abstract Glioma stem cells (GSCs) exhibit significant resistance to conventional radiotherapy and chemotherapy, contributing to high recurrence rates in gliomas. Addressing this critical clinical need, we developed DMC-GF, a novel GLUT1-based curcumin derivative, to enhance brain specificity and met...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Lei Shi, Xifeng Fei, Jian Huang, Bao He, Zhixiang Sun, Guan Sun
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	DMC-BH DMC-GF Glioma stem cells GLUT1 SLC25A1
Online Access:	https://doi.org/10.1186/s12967-025-06355-z