Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation

Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to un...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Immunology
المؤلفون الرئيسيون: Daniela Pende, Michela Falco, Massimo Vitale, Claudia Cantoni, Chiara Vitale, Enrico Munari, Alice Bertaina, Francesca Moretta, Genny Del Zotto, Gabriella Pietra, Maria Cristina Mingari, Franco Locatelli, Lorenzo Moretta
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2019-05-01
الموضوعات:
HLA class I
killer immunoglobulin-like receptors
KIR ligands
inhibitory checkpoints
NK alloreactivity
NK cell education
الوصول للمادة أونلاين:https://www.frontiersin.org/article/10.3389/fimmu.2019.01179/full

الانترنت

https://www.frontiersin.org/article/10.3389/fimmu.2019.01179/full

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