RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes

Abstract Epidermal keratinocytes are a major source of antimicrobial peptides and proteins. RNase 7 (R7) exhibits antimicrobial and immunomodulatory activities and is upregulated in the lesional skin of atopic dermatitis and psoriasis patients. Here, we performed mRNA microarray analysis to study th...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Shruti Chopra, Janine Siegl, Verena Kopfnagel, Sylvia Dreyer, Franziska Rademacher, Juliane Lokau, Christoph Garbers, Jürgen Harder, Thomas Werfel, Katinka Döhner
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Subjects:	RNase 7 IL-6 IL-24 IL-17 IFN-γ Inflammatory skin diseases
Online Access:	https://doi.org/10.1038/s41598-025-04403-8