Hereditary Spastic Paraplegia: From Genes, Cells and Networks to Novel Pathways for Drug Discovery

Hereditary spastic paraplegia (HSP) is a diverse group of Mendelian genetic disorders affecting the upper motor neurons, specifically degeneration of their distal axons in the corticospinal tract. Currently, there are 80 genes or genomic loci (genomic regions for which the causative gene has not bee...

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Bibliographic Details

Published in:	Brain Sciences
Main Author:	Alan Mackay-Sim
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Subjects:	neurodegeneration motor neuron disease spastic paraplegia endoplasmic reticulum protein-protein interaction network
Online Access:	https://www.mdpi.com/2076-3425/11/3/403