Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling

Abstract Prototypic receptors for human influenza viruses are N-glycans carrying α2,6-linked sialosides. Due to immune pressure, A/H3N2 influenza viruses have emerged with altered receptor specificities that bind α2,6-linked sialosides presented on extended N-acetyl-lactosamine (LacNAc) chains. Here...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Luca Unione, Augustinus N. A. Ammerlaan, Gerlof P. Bosman, Elif Uslu, Ruonan Liang, Frederik Broszeit, Roosmarijn van der Woude, Yanyan Liu, Shengzhou Ma, Lin Liu, Marcos Gómez-Redondo, Iris A. Bermejo, Pablo Valverde, Tammo Diercks, Ana Ardá, Robert P. de Vries, Geert-Jan Boons
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Online Access:	https://doi.org/10.1038/s41467-024-47344-y