Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity

Objective: Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain. Bitter compounds are known to induce satiety via the release of glucagon-like peptide 1 (GLP-1) through activation...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Qian Wang, Mona Farhadipour, Theo Thijs, Emily Ruilova Sosoranga, Bart Van der Schueren, Laurens J. Ceulemans, Ellen Deleus, Matthias Lannoo, Jan Tack, Inge Depoortere
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	GDF15 GLP-1 Obesity Bitter Motilin receptor Integrated stress response pathway
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824001339