ChromInSight: Revealing DNA Double‐Strand Breaks Through Chromatin Structural Insights With an Interpretable Graph Neural Network Framework

Abstract DNA double‐strand breaks (DSBs) represent one of the most severe forms of genomic damage. Although substantial progress has been made in elucidating general patterns associated with DSBs, the influence of 3D chromatin structure on DSB formation remains underexplored, particularly concerning...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Kang Xu, Zongyuan Yu, Canzhuang Sun, Conglin Gou, Jiangyue Zhu, Jun Wang, Xiaochen Bo, Guoxian Yu, Hao Li, Hebing Chen
Format:	Article
Language:	English
Published:	Wiley 2025-09-01
Subjects:	DSB Graph Contrastive Learning 3D Chromatin Spatial Conformation Benchmark
Online Access:	https://doi.org/10.1002/advs.202504571