The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING). This finally promotes the production of type I interferons (IFN-I) that is cruc...

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Bibliographic Details

Published in:	Medical Review
Main Authors:	Zhou Zheqi, Huang Sanling, Fan Fangying, Xu Yan, Moore Casey, Li Sirui, Han Chuanhui
Format:	Article
Language:	English
Published:	De Gruyter 2024-06-01
Subjects:	cgas sting agonist ifn-i tumor
Online Access:	https://doi.org/10.1515/mr-2023-0061