Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Abstract The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune respo...

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Bibliographic Details

Published in:	Protein & Cell
Main Authors:	Mi Li, Hong-Bing Shu
Format:	Article
Language:	English
Published:	Oxford University Press 2020-05-01
Subjects:	DNA virus PPP6C cGAS innate immune response phosphorylation substrate binding
Online Access:	https://doi.org/10.1007/s13238-020-00729-3