Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

Abstract The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the pathogenic disease-associated forms of α-synuclein (αSynD) that are sufficiently sensitive, specific, and practical for analysis of a...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Acta Neuropathologica Communications
المؤلفون الرئيسيون: Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko, Byron Caughey
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2018-02-01
الموضوعات:
Parkinson
Lewy body
Alzheimer
Diagnosis
Synuclein
Amplification
الوصول للمادة أونلاين:http://link.springer.com/article/10.1186/s40478-018-0508-2

الانترنت

http://link.springer.com/article/10.1186/s40478-018-0508-2

مواد مشابهة