Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations

Pathogenic <i>Acanthamoeba</i> produce keratitis and fatal granulomatous amoebic encephalitis. Treatment remains problematic and often ineffective, suggesting the need for the discovery of novel compounds. For the first time, here we evaluated the effects of the anticancer drugs Irosusta...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Ruqaiyyah Siddiqui, Mutasem Rawas-Qalaji, Mohammed I. El-Gamal, Sreedevi Sajeev, Jayalakshmi Jagal, Seyed-Omar Zaraei, Rawan M. Sbenati, Hanan S. Anbar, Wolfgang Dohle, Barry V. L. Potter, Naveed Ahmed Khan
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	<i>Acanthamoeba castellanii</i> CNS infections free-living amoebae irosustat PLGA nanoparticles STX140
Online Access:	https://www.mdpi.com/2079-6382/12/3/561