Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway

Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through...

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Bibliographic Details

Published in:	Journal of Ginseng Research
Main Authors:	Xiang Xu, Yu-Nan Lu, Jia-Hui Cheng, Hui-Wen Lan, Jing-Mei Lu, Guang-Nan Jin, Guang-Hua Xu, Cheng-Hua Jin, Juan Ma, Hu-Nan Piao, Xuejun Jin, Lian-Xun Piao
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	Ginsenoside Rh2 Microglia Offspring Psychiatric disorders Toxoplasma gondii
Online Access:	http://www.sciencedirect.com/science/article/pii/S1226845321000452