Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment

The prevailing paradigm states that cancer cells acquire multiple genetic mutations in oncogenes or tumor suppressor genes whose respective activation/up-regulation or loss of function serve to impart aberrant properties, such as hyperproliferation or inhibition of cell death. However, a tumor is no...

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Bibliographic Details

Published in:	Marine Drugs
Main Authors:	Carlos M. Galmarini, Maurizio D'Incalci, Paola Allavena
Format:	Article
Language:	English
Published:	MDPI AG 2014-01-01
Subjects:	trabectedin plitidepsin tumor-associated macrophages tumor microenvironment
Online Access:	http://www.mdpi.com/1660-3397/12/2/719