SNF2L maintains glutathione homeostasis by initiating SLC7A11 transcription through chromatin remodeling

Abstract SNF2L encodes an ISWI chromatin remodeling factor that promotes gene transcription and is consistently elevated in cancers. Previous studies have shown that inhibiting SNF2L expression in cancer cells leads to significant growth suppression, DNA damage, and cell death. However, the underlyi...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Jiaguan Zhang, Zeshou Gao, Yi Yang, Zhenhao Li, Binjie Wu, Chunxin Fan, Yuyan Zheng, Ruohan Yang, Fangrong Zhang, Xiaohuang Lin, Daoshan Zheng
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-11-01
Online Access:	https://doi.org/10.1038/s41419-024-07221-4