Prospects for the computational humanization of antibodies and nanobodies

To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the ‘humanness’ of the candidate drug. However, despite the emergence of new discovery technologies, many of which start from entir...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Gemma L. Gordon, Matthew I. J. Raybould, Ashley Wong, Charlotte M. Deane
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	humanization humanness antibody nanobody computational therapeutics
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399438/full