A severe leakage of intermediates to shunt products in acarbose biosynthesis
Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the flux to these shunt products can increase acarb...
| Published in: | Nature Communications |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Online Access: | https://doi.org/10.1038/s41467-020-15234-8 |