Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson’s Disease

AimTo investigate the role of histone deacetylase 6 (HDAC6) deacetylation activity in nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammatory response and explore the effects of pharmacological inhibition of HDAC6 with tubastatin A (TBA) on dopaminergic...

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Bibliographic Details
Published in:Frontiers in Aging Neuroscience
Main Authors: Shaoqi Yan, Xinbing Wei, Wencheng Jian, Yue Qin, Jia Liu, Shaowei Zhu, Fan Jiang, Haiyan Lou, Bin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Subjects:
HDAC6
NLRP3
Parkinson’s disease
peroxiredoxin 2
tubastatin A
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00078/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00078/full

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