Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment

The combination of folinic acid, 5-fluorouracil, oxaliplatin and/or irinotecan (FOLFOXIRI) is the standard of care for metastatic colorectal cancer (CRC). This strategy inhibits tumor growth but provokes drug resistance and serious side effects. We aimed to improve FOLFOXIRI by optimization of the d...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Marloes Zoetemelk, George M. Ramzy, Magdalena Rausch, Patrycja Nowak-Sliwinska
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Subjects:	colorectal carcinoma (CRC) drug-drug interaction optimized drug combination treatment schedule synergy
Online Access:	https://www.mdpi.com/1420-3049/25/11/2614