Neurogranin-MYH9 interaction regulates cytoskeletal remodeling in cerebral vasculature

Abstract Neurogranin (Ng), a known regulator of neuronal Ca²⁺-calmodulin (CaM) signaling, is linked to Alzheimer’s disease. Though well-studied in neurons, Ng is also expressed in brain vasculature, where its function remains unclear. To investigate Ng’s role in brain microvascular endothelial cells...

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Bibliographic Details

Published in:	Fluids and Barriers of the CNS
Main Authors:	Adesewa Akande, Ji Eun Park, Rona Scott, J. Steven Alexander, Hyung W. Nam
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Neurogranin Immunoprecipitation-mass spectrometry Interactome Myosin-9 Cytoskeletal remodeling
Online Access:	https://doi.org/10.1186/s12987-025-00709-x