Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma

Abstract Clinically, histotripsy utilizes a fixed, non-optimized dose (defined by the number of histotripsy pulses) to non-invasively ablate liver tumors. This study investigates the impact of histotripsy doses on tumor cellular damage, immune response, and treatment outcomes. Single orthotopic rat...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Tejaswi Worlikar, Man Zhang, Menggang Yu, Hanna Kim, Jiaqi Shi, Timothy L. Hall, Mishal Mendiratta-Lala, Clifford S. Cho, Zhen Xu
Format: Article
Language:English
Published: Nature Portfolio 2026-04-01
Subjects:
Histotripsy
Cancer
Dose optimization
Immune effects
Abscopal effects
Cellular damage
Online Access:https://doi.org/10.1038/s41598-026-48331-7

Internet

https://doi.org/10.1038/s41598-026-48331-7

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