Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment

The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we identified tofacitinib, a pa...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Christine Lam, Ian D. Ferguson, Margarette C. Mariano, Yu-Hsiu T. Lin, Megan Murnane, Hui Liu, Geoffrey A. Smith, Sandy W. Wong, Jack Taunton, Jun O. Liu, Constantine S. Mitsiades, Byron C. Hann, Blake T. Aftab, Arun P. Wiita
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2018-07-01
Online Access:	https://haematologica.org/article/view/8526