Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy

Tetrandrine (TET), a natural bisbenzyl isoquinoline alkaloid extracted from Stephania tetrandra S. Moore, has diverse pharmacological effects. However, its effects on melanoma remain unclear. Cellular proliferation assays, multi-omics analyses, and xenograft models were used to determine the effect...

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الحاوية / القاعدة:	Journal of Pharmaceutical Analysis
المؤلفون الرئيسيون:	Yacong Ji, Chongyang Li, Sicheng Wan, Zhen Dong, Chaolong Liu, Leiyang Guo, Shaomin Shi, Mingxin Ci, Minghao Xu, Qian Li, Huanrong Hu, Hongjuan Cui, Yaling Liu
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2024-10-01
الموضوعات:	Melanoma Tetrandrine Sirtuin 5 (SIRT5) Mitophagy Cytoskeletal protein depolymerization Reactive oxygen species (ROS)
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2095177924001333