Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is a common age-related neurodegenerative disease that leads to memory loss and cognitive function damage due to intracerebral neurofibrillary tangles (NFTs) and amyloid-β (Aβ) protein deposition. The phosphoinositide-dependent protein kinase (PDK1)/protein kinase B (Akt) si...

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Bibliographic Details

Published in:	Cells
Main Authors:	Shaobin Yang, Yaqin Du, Xiaoqian Zhao, Chendong Wu, Peng Yu
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Subjects:	Alzheimer’s disease amyloid-β Tau 3-phosphoinositide dependent kinase 1 protein kinase B phosphoinositide 3-kinase
Online Access:	https://www.mdpi.com/2073-4409/11/11/1735