Permissive immunosuppression facilitates the expansion of ex vivo administered regulatory T cells in the lung allograft

Abstract In lung transplantation (LT), alloreactive T cell priming begins in the graft, a process that can be inhibited by seeding the graft with recipient-derived expanded polyclonal regulatory T cells (Tregs) using ex vivo lung perfusion (EVLP) prior to transplantation. However, this therapy alone...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Akihiro Takahagi, Ei Miyamoto, Christina Lam, Mingyao Liu, Betty Joe, Xiaomin Wang, David Hwang, Tereza Martinu, Marcelo Cypel, Shaf Keshavjee, Stephen Juvet
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41598-025-06835-8