Trematocine-derived antimicrobial peptides from the Antarctic fish Trematomus bernacchaii: potent antibacterial agents against ESKAPE pathogens

IntroductionThis study investigated the interaction with membrane mimetic systems (LUVs), bacterial membranes, the CD spectra, and the bactericidal activity of two designed trematocine mutants, named Trem-HK and Trem-HSK. Mutants were constructed from the scaffold of Trematocine (Trem), a natural 22...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Damiano Squitieri, Federica Massaro, Monica Mollica Graziano, Stefano Borocci, Margherita Cacaci, Maura Di Vito, Fernando Porcelli, Roberto Rosato, Francesca Ceccacci, Maurizio Sanguinetti, Francesco Buonocore, Francesca Bugli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	antimicrobial peptides antimicrobial resistance ESKAPE pathogens membranolytic agents multi-drug resistant bacteria
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1447301/full