Inoculum Concentration Influences Pseudomonas aeruginosa Phenotype and Biofilm Architecture

ABSTRACT In infections, bacterial cells are often found as relatively small multicellular aggregates characterized by a heterogeneous distribution of phenotype, genotype, and growth rates depending on their surrounding microenvironment. Many laboratory models fail to mimic these characteristics, and...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Mads Lichtenberg, Lasse Kvich, Sara Louise Borregaard Larsen, Tim Holm Jakobsen, Thomas Bjarnsholt
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-12-01
Subjects:	alginate bead biofilm microenvironment oxygen Pseudomonas aeruginosa model system
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.03131-22