Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.

The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which have a cysteine-rich domain (CRD) structurally...

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Published in:	PLoS ONE
Main Authors:	Ismaïl Hendaoui, Elise Lavergne, Heun-Sik Lee, Seong Hyun Hong, Hak-Zoo Kim, Christelle Parent, Nathalie Heuzé-Vourc'h, Bruno Clément, Orlando Musso
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3267734?pdf=render